1. Behavioural and psychological interventions
1.1 Multicomponent interventions
We recommend using multicomponent interventions (i.e., at least 2 of physical activity, nutrition, psychology, and technology interventions) for managing obesity in children aged 18 years and younger.
Strength of recommendations; certainty of evidence: Strong; very moderate to low certainty
Rationale: For critically important and very important outcomes, compared with minimal interventions, multicomponent interventions had a small effect on depression, anxiety, and BMIz. Interventions had little to no effect on HRQoL. No serious AEs were reported in any multicomponent intervention studies. When mild to moderate AEs were reported, they were trivial.
1.2 Nutrition interventions
We suggest using nutritional interventions for managing obesity in children aged 18 years and younger.
Strength of recommendations; certainty of evidence: Conditional; very low to low certainty
Rationale: For critically important outcomes, no data were available, but for our very important outcome (BMIz), compared with minimal interventions, nutrition interventions had a small beneficial effect. No serious AEs were reported in any nutrition intervention studies. When mild to moderate AEs were reported, they were trivial. This recommendation relates to nutrition interventions exclusively, not in conjunction with other interventions.
1.3 Physical activity interventions
We suggest using physical activity interventions for managing obesity in children aged 18 years and younger.
Strength of recommendations; certainty of evidence: Conditional; very low to low certainty
Rationale: For critically important and very important outcomes, intervention effects were small for HRQoL and BMIz; for depression and anxiety, there were little to no effects. No serious AEs were reported in any physical activity intervention studies. On rare occasions when mild to moderate AEs were reported, they included musculoskeletal injuries (e.g., mild ankle sprain) or discomfort (e.g., postexertional malaise). This recommendation relates to physical activity interventions exclusively, not in conjunction with other interventions.
1.4 Psychological interventions
We suggest using psychological interventions for managing obesity in children aged 18 years and younger.
Strength of recommendations; certainty of evidence: Conditional; very low to moderate certainty
Rationale: For critically important outcomes, intervention effects for depression were moderate and small for HRQoL; no anxiety data were reported. For our very important outcome (BMIz), psychological interventions resulted in little to no effect. There was no evidence of serious AEs and very little evidence of mild to moderate AEs from psychological interventions. This recommendation relates to psychological interventions exclusively, not in conjunction with other interventions.
1.5 Technology interventions
We recommend neither for nor against using technology interventions for managing obesity in children aged 18 years and younger.
Strength of recommendations; certainty of evidence: Conditional; very low to low certainty
Rationale: For all critically important outcomes, there were little to no effects of technology interventions on HRQoL, depression, or anxiety. For our very important outcome, there was a small beneficial effect on BMIz. There was no evidence of serious (critically important outcome) or mild to moderate (important outcome) AEs. This recommendation relates to technology interventions exclusively, not in conjunction with other interventions.
2. Pharmacologic interventions
2.1 Glucagon-like peptide-1 receptor agonists
We suggest that glucagon-like peptide-1 receptor agonists be considered, in combination with behavioural and psychological interventions, for managing obesity in children aged 12 years and older.
Strength of recommendations; certainty of evidence: Conditional; very low to low certainty
Rationale: Overall, for critically important outcomes, GLP-1RAs had little to no effect on HRQoL; no data were available on depression and anxiety. For our very important outcome (BMIz), GLP-1RAs may result in a small reduction in BMIz. Subgroup analyses showed that semaglutide had more substantial effects on HRQoL (small effect) and BMIz (very large effect), along with effects on several other important outcomes, versus other GLP-1RAs. Evidence regarding an increased risk of serious AEs (a critically important outcome) with GLP-1RAs was uncertain. There may be a small increased risk in mild to moderate AEs with GLP-1RAs, but the risk appeared to vary. Most of the evidence supporting this recommendation was derived from children aged 12 years and older. The effectiveness and safety of GLP-1RAs for children younger than 12 years has not been evaluated. Studies that examined the effects of GLP-1RAs included concurrent behavioural and psychological interventions, which varied study to study.
2.2 Biguanides
We suggest that biguanides be considered, in combination with behavioural and psychological interventions, for managing obesity in children aged 12 years and older.
Strength of recommendations; certainty of evidence: Conditional; low to moderate certainty
Rationale: For critically important outcomes, biguanides (e.g., metformin) had little to no effect on HRQoL; no data were reported on anxiety and depression. For our very important outcome (BMIz), biguanides had a moderate effect. Biguanides resulted in no serious AEs (critically important outcome) but may result in more mild to moderate AEs than in controls. Most of the evidence supporting this recommendation was derived from children aged 12 years and older. Studies that examined the effects of biguanides included concurrent behavioural and psychological interventions, which varied study to study.
2.3 Lipase inhibitors
We suggest against using lipase inhibitors for managing obesity in children.
Strength of recommendations; certainty of evidence: Conditional; low certainty
Rationale: There was a lack of evidence for the effects of lipase inhibitors (e.g., orlistat) on critically important (HRQoL, anxiety, depression) and very important (BMIz) outcomes. Lipase inhibitor use may result in more cases of serious AEs (a critically important outcome) and more cases of mild to moderate AEs (e.g., gastrointestinal) than in controls. Most of the evidence supporting this recommendation was derived from children aged 12 years and older. Studies that examined the effects of lipase inhibitors included concurrent behavioural and psychological interventions, which varied study to study.
3. Surgical interventions
3.1 Laparoscopic sleeve gastrectomy
We suggest that laparoscopic sleeve gastrectomy be considered, in combination with behavioural and psychological interventions, for managing obesity in children aged 13 years and older who are deemed eligible candidates based on a comprehensive health assessment by a specialized, multidisciplinary team.
Strength of recommendations; certainty of evidence: Conditional; low to moderate certainty
Rationale: For critically important outcomes, LSG had a very large effect on HRQoL; no data were reported on anxiety and depression. For very important outcomes, weight and BMI decreased substantially. For undesirable effects, LSG may result in a higher incidence of serious AEs (a critically important outcome) and mild to moderate AEs (an important outcome). The effectiveness and safety of LSG were evaluated in individuals who were almost exclusively aged 13 years and older and in combination with behavioural and psychological interventions, which varied study to study.
3.2 Roux-en-Y gastric bypass
We suggest that Roux-en-Y gastric bypass be considered, in combination with behavioural and psychological interventions, for managing obesity in children aged 13 years and older who are deemed eligible candidates based on a comprehensive health assessment by a specialized, multidisciplinary team.
Strength of recommendations; certainty of evidence: Conditional; low to moderate certainty
Rationale: For critically important outcomes, RYGB had a large effect on HRQoL and small effects on anxiety and depression. For very important outcomes, RYGB led to substantial reductions in weight and BMI. For undesirable effects, RYGB may result in higher incidence of serious AEs (a critically important outcome) and mild to moderate AEs (an important outcome). The effectiveness and safety of RYGB were evaluated in individuals who were almost exclusively aged 13 years and older and in combination with behavioural and psychological interventions, which varied study to study.
Note: AE = adverse event, BMI = body mass index, BMIz = body mass index z score, GLP-1RA = glucagon-like peptide-1 receptor agonists, GRADE = Grading of Recommendations Assessment, Development and Evaluation, HRQoL = health-related quality of life, LSG = laparoscopic sleeve gastrectomy, RYGB = Roux-en-Y gastric bypass.
*GRADE certainty of evidence(18) for behavioural and psychological, pharmacologic, and surgical interventions was based on critically important (HRQoL, depression, anxiety, and serious AEs) and very important outcomes (BMIz for behavioural and psychological and pharmacotherapy interventions; BMI and weight for surgery) only. Ranges were included for certainty of evidence ratings based on recommendations from the guideline panel and variability in the certainty of evidence across critically important and very important outcomes. Most panellists with lived experience placed higher value on improvements in HRQoL, depression, anxiety, serious AEs, and BMIz (or BMI and weight) than other outcomes.